Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/8637
Title: Psychotria viridis : chemical constituents from leaves and biological properties.
Authors: Soares, Débora Barbosa da Silva
Duarte, Lucienir Pains
Cavalcanti, André D.
Silva, Fernando César
Braga, Ariadne Duarte
Lopes, Miriam Teresa Paz
Takahashi, Jacqueline Aparecida
Vieira Filho, Sidney Augusto
Keywords: Rubiaceae
Issue Date: 2017
Citation: SOARES, D. B. S. et al. Psychotria viridis : chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017.
Abstract: The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.
URI: http://www.repositorio.ufop.br/handle/123456789/8637
ISSN: 16782690
metadata.dc.rights.license: Todo o conteúdo do periódico Anais da Academia Brasileira de Ciências, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Anais da Academia Brasileira de Ciências <http://www.scielo.br/scielo.php?script=sci_serial&pid=0001-3765&lng=en&nrm=iso>. Acesso em: 14 out. 2016.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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