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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Sousa, Grasiely Faria de | - |
dc.contributor.author | Aguilar, Mariana Guerra de | - |
dc.contributor.author | Dias, Danielle Ferreira | - |
dc.contributor.author | Takahashi, Jacqueline Aparecida | - |
dc.contributor.author | Moreira, Maria Eliza de Castro | - |
dc.contributor.author | Vieira Filho, Sidney Augusto | - |
dc.contributor.author | Silva, Grácia Divina de Fátima | - |
dc.contributor.author | Rodrigues, Salomão Bento Vasconcelos | - |
dc.contributor.author | Messias, Maria Cristina Teixeira Braga | - |
dc.contributor.author | Duarte, Lucienir Pains | - |
dc.date.accessioned | 2017-08-31T15:49:09Z | - |
dc.date.available | 2017-08-31T15:49:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | SOUSA, G. F. et al. Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities of friedelanes from Maytenus robusta branches and isolation of further triterpenoids. Phytochemistry Letters, v. 21, p. 61-65, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1874390017301659>. Acesso em: 29 ago. 2017. | pt_BR |
dc.identifier.issn | 1874-3900 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/8636 | - |
dc.description.abstract | The new pentacyclic triterpenoids friedel-1-en-3,16-dione (1), 1α,29-dihydroxyfriedelan-3-one (2) and 16β,28,29-trihydroxyfriedelan-3-one (3) were isolated from Maytenus robusta branches in addition to the known, but new for this species, triterpenoid 12α,29-dihydroxyfriedelan-3-one (4). The structures and stereochemistry of the novel triterpenoids were established by IR, 1D/2D NMR and HR-APCIMS spectral data. In addition, the biological activity of compound 2 and the previously isolated friedelanes 5–8 (friedelan-3,16-dione, 29-hydroxyfriedelan- 3-one, 29-hydroxyfriedelan-3,16-dione and 16β,29-dihydroxyfriedelan-3-one) was investigated. Compounds 2 and 8 were tested for their acetylcholinesterase properties and antimicrobial activity against the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, Listeria monocytogenes, Citrobacter freundii, and the fungus Candida albicans. Compound 2 was the most active compound for both assays, with values of 32.3% acetylcholinesterase inhibition, 42% activity against the fungus Candida albicans and 34% against the bacterium Pseudomonas aeruginosa. Compounds 5–8 were assayed for their antiedematogenic activity using the carrageenan- induced paw edema assay. At maximum inflammation after three hours, compounds 6 and 8 showed 42% and 57% activity, respectively. After four hours, compounds 5 and 7 showed activity of 71% and 75% compared to 79% of the control indomethacin. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.title | Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities of friedelanes from Maytenus robusta branches and isolation of further triterpenoids. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | O periódico Phytochemistry Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4178720474114. | - |
dc.identifier.doi | https://doi.org/10.1016/j.phytol.2017.05.026 | - |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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