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Title: Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituents.
Authors: Brandão, Geraldo Célio
Kroon, Erna Geessien
Souza Filho, José Dias de
Oliveira, Alaíde Braga de
Issue Date: 2017
Citation: BRANDÃO, G. C. et al. Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituents. Journal of Tropical Medicine, v. 2017, p. 1-11, 2017. Disponível em: <>. Acesso em: 29 ago. 2017.
Abstract: A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WRwith best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WRand HSV-1, EC50 values > 200 𝜇g mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2󸀠-O-trans-caffeoylmangiferin (2), 2󸀠-O-trans-coumaroylmangiferin (3), 2󸀠- O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2󸀠-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs.
ISSN: 1995-7645
metadata.dc.rights.license: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.
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