Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/8456
Title: Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances.
Authors: Nascimento, Adriana Mendes do
Soares, Mateus Gonçalves
Torchelsen, Fernanda Karoline Vieira da Silva
Araújo, Jorge Augusto Viana de
Lage, Paula Souza
Duarte, Mariana Costa
Andrade, Pedro Henrique Rocha de
Ribeiro, Tatiana Gomes
Coelho, Eduardo Antônio Ferraz
Nascimento, Andréa Mendes do
Keywords: Endophytes
Bioprospection
Leishmania amazonensis
Issue Date: 2015
Citation: NASCIMENTO, A. M. do et al. Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances. World Journal of Microbiology & Biotechnology, v. 31, p. 1793-1800, 2015. Disponível em: <https://link.springer.com/article/10.1007%2Fs11274-015-1932-0>. Acesso em: 05 ago. 2017.
Abstract: The purpose of this work was to evaluate the antileishmanial activity of endophytic fungi isolated from leaves of Vernonia polyanthes plant and their prospective use in the discovery of bioactive compounds. Sixteen endophytes were isolated by using potato dextrose agar medium and submitted to cultivation in rice medium. The fungal cultures were extracted with ethanol and used as crude extracts for testing their antileishmanial activity. The most active ethanol extract was obtained from P2-F3 strain, which was identified as Cochliobolus sativus by ITS rRNA gene sequence data. Followed by a bioassay-guided fractionation, the cochlioquinone A, isocochlioquinone A and anhydrocochlioquinone A compounds were isolated from the crude extracts and demonstrated to inhibit the parasites. From the present work, it is possible to conclude that endophytic fungi derived from medicinal plant V. polyanthes may be considered promising source for the discovery of bioactive compounds.
URI: http://www.repositorio.ufop.br/handle/123456789/8456
metadata.dc.identifier.uri2: https://link.springer.com/article/10.1007%2Fs11274-015-1932-0
ISSN: 15730972
Appears in Collections:DEQUI - Artigos publicados em periódicos

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