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Title: Immune network at the edge of chaos.
Authors: Bernardes, Américo Tristão
Santos, Rita Maria Zorzenon dos
Issue Date: 1997
Citation: BERNARDES, A. T. ; SANTOS, R. M. Z. dos. Immune Network at the Edge of Chaos. Journal of Theoretical Biology, v. 186, n. 2, p. 173-187, 1997. Disponível em: <>. Acesso em: 14 jun. 2012.
Abstract: Some time ago Jerne proposed a new theory to explain the basis of the behaviour of the immune system. He suggested the existence of a functional connected network, based on pattern recognition of the idiotypes carried by the lymphocytes, which is responsible for the self regulation of the immune system. Only 04 19) of the lymphocytes available in the immune repertoire will participate in this functional network, while the rest of the lymphocytes will be free to respond to any foreign antigen. Each individual immune repertoire will be different depending on the lymphocytes that participate in the connected network. Using a very simple cellular automata model of the immune repertoire dynamics we show that, although the usual regimes "stable and chaotic# attained by this automata, are not interesting from the biological point of view, the transition region, at the edge of chaos, is very appropriate to describe such dynamics[ In this region we have obtained a functional connected network involving 09 19) of the lymphocytes available in the repertoire, as suggested by Jerne and others[ The model also reproduces the immune system signature, the ensemble of different lymphocytes that each individual expresses in his immune repertoire, which varies from one individual to another[ We show how the immune memory comes out as a consequence of the dynamics of the system[ From our results we confirm and present evidence that the chaotic regime corresponds to a sort of non- healthy state, as has been suggested previously.
ISSN: 00225193
metadata.dc.rights.license: O Periódico Journal of Theoretical Biology concede permissão para depósito do artigo no Repositório Institucional da UFOP. Número da licença: 3316990223682.
Appears in Collections:DEFIS - Artigos publicados em periódicos

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