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Title: Cytotoxicity, anti-poliovirus activity and in silico biological evaluation of constituents from Maytenus gonoclada (Celastraceae).
Authors: Oliveira, Mauro Lúcio Gonçalves de
Assenço, Regina Aparecida Gomes
Silva, Grácia Divina de Fátima
Lopes, Júlio César Dias
Silva, Fernando César
Lanna, Maria Célia da Silva
Magalhães, José Carlos de
Duarte, Lucienir Pains
Vieira Filho, Sidney Augusto
Keywords: VERO cells Cytotoxicity
PASS online
Issue Date: 2014
Citation: OLIVEIRA, M. L. G. de et al. Cytotoxicity, anti-poliovirus activity and in silico biological evaluation of constituents from Maytenus gonoclada (Celastraceae). International Journal of Pharmacy and Pharmaceutical Sciences, v. 6, p. 130-137, 2014. Disponível em: <>. Acesso em: 16 jun. 2017.
Abstract: Objective: The in silico free access web tools PASS online and ChemMapper were used to predict potential biological activities of compounds 1 to 8 isolated from Maytenus gonoclada (Celastraceae). The constituents 4’-O-methylepigalocatequin (6), tingenone (7) and proanthocyanidin A (8), and ethanolic extracts were subjected to in vitro cytotoxicity using VERO cells and anti-Poliovirus assays. Methods: QSAR and molecular superposition, correlating the average number of pharmacophores were used in the prediction studies. Cellular line VERO ATCC CCL-81 was used to determine anti-Poliovirus effect, observed by colorimetric (MTT) method. The annexing V/propidium iodide assay was used to determine the occurrence of apoptosis in the cytotoxicity assays. Results: The experimental results found for constituents 6-8 were in accordance with observed data obtained through PASS online and ChemMapper simulation. Conclusion: Compound 7 showed higher cytotoxic and apoptosis induction properties, and 6 and 8 presented anti-Poliovirus activity.
ISSN: 0975-1491
Appears in Collections:DEFAR - Artigos publicados em periódicos

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