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Title: Exposure to cigarette smoke during pregnancy causes redox imbalance and histological damage in lung tissue of neonatal mice.
Authors: Campos, Keila Karine Duarte
Dourado, Vitor Alves
Diniz, Mirla Fiuza
Bezerra, Frank Silva
Lima, Wanderson Geraldo de
Keywords: Oxidative stress
Issue Date: 2014
Citation: CAMPOS. K. K. D. et al. Exposure to cigarette smoke during pregnancy causes redox imbalance and histological damage in lung tissue of neonatal mice. Experimental Lung Research, v. 40, p. 164-171, 2014. Disponível em: <>. Acesso em: 19 fev. 2017.
Abstract: Smoking during pregnancy is directly associated with numerous serious conditions, such as premature birth, low birth weight, and perinatal mortality. We quantitatively evaluated histological inflammatory alterations, oxidative damage by lipid peroxidation, the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the lungs of mice exposed to cigarette smoke during pregnancy. Eight female and four male mice were mated for five days. Pregnant female mice were randomly allocated to the control group or to the cigarette smoke group (n = 8) in which they were exposed to 12 cigarettes per day in an exposure chamber, three times a day for 21 days. The control group (CG; n = 8) was kept in the exposure chamber for the same duration, but without exposure to cigarette smoke. Six newborn mice from both groups were weighed 24 hours after birth and then euthanized. Lung tissue was collected and subjected to histomorphometric and biochemical analyses. The cigarette smoke group showed a significant reduction in snout-vent length compared to the control group. Histomorphometric analysis indicated increased alveolar septal thickness and a larger alveolar lumen in mice exposed to cigarette smoke than in mice in the control group. We observed increased alveolar inflammatory infiltrate, decreased SOD activity, and significantly higher oxidative damage in the cigarette smoke group. Our data indicate that cigarette smoke exposure during pregnancy decreases body length at birth, changes lung tissue, and causes redox imbalance and histological damage in newborn mice.
ISSN: 1521-0499
Appears in Collections:DECBI - Artigos publicados em periódicos

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