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Title: Vaccination with enzimatically cleaved GPI-anchored proteins from Schistosoma mansoni induced protection against challenge infection.
Authors: Martins, Vicente de Paulo
Pinheiro, Carina da Silva
Figueiredo, Bárbara de Castro Pimentel
Assis, Natan Raimundo Gonçalves de
Morais, Suellen Batistoni de
Caliari, Marcelo Vidigal
Azevedo, Vasco Ariston de Carvalho
Borges, William de Castro
Wilson, R. Alan
Oliveira, Sergio Costa
Issue Date: 2012
Citation: MARTINS, V. de P. et al. Vaccination with enzimatically cleaved GPI-anchored proteins from Schistosoma mansoni induced protection against challenge infection. Clinical and Developmental Immunology, v. 2012, p. e962538, 2012. Disponível em: <>. Acesso em: 20 mar. 2017.
Abstract: The flatworm Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating disease that occurs throughout the developing world. Current schistosomiasis control strategies are mainly based on chemotherapy, but many researchers believe that the best long-termstrategy to control schistosomiasis is through immunization with an antischistosomiasis vaccine combined with drug treatment. In the search for potential vaccine candidates, numerous tegument antigens have been assessed. As the major interface between parasite and mammalian host, the tegument plays crucial roles in the establishment and further course of schistosomiasis. Herein, we evaluated the potential of a GPI fraction, containing representative molecules located on the outer surface of adult worms, as vaccine candidate. Immunization of mice with GPI-anchored proteins induced a mixed Th1/Th2 type of immune response with production of IFN-γ and TNF-α, and low levels of IL-5 into the supernatant of splenocyte cultures. The protection engendered by this vaccination protocol was confirmed by 42% reduction in worm burden, 45% reduction in eggs per gram of hepatic tissue, 29% reduction in the number of granulomas per area, and 53% reduction in the granuloma fibrosis. Taken together, the data herein support the potential of surface-exposed GPI-anchored antigens from the S. mansoni tegument as vaccine candidate.
ISSN: 2314-7156
metadata.dc.rights.license: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.
Appears in Collections:DECBI - Artigos publicados em periódicos

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