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Title: Calcium handling proteins : structure, function, and modulation by exercise.
Authors: Locatelli, Jamille
Assis, Leonardo Vinícius Monteiro de
Isoldi, Mauro César
Keywords: Hypertrophy
Physical exercise
Heart failure
Issue Date: 2013
Citation: LOCATELLI, J.; ASSIS, L. V. M. de; ISOLDI, M. C. Calcium handling proteins: structure, function, and modulation by exercise. Heart Failure Reviews, v. 19, p. 207-225, 2013. Disponível em: <>. Acesso em: 23 fev. 2017.
Abstract: Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation–contraction process in the heart among those are sarcoplasmic reticulum Ca2?-ATPase, phospholamban, calsequestrin, sodium–calcium exchanger, L-type calcium’s channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.
ISSN: 1573-7322
Appears in Collections:DECBI - Artigos publicados em periódicos

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