Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7981
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dc.contributor.authorVieira, Flaviana Tavares-
dc.contributor.authorMaia, José Roberto da Silveira-
dc.contributor.authorVilela, Marcelo José-
dc.contributor.authorArdisson, José Domingos-
dc.contributor.authorSantos, Marcelo Henrique dos-
dc.contributor.authorOliveira, Tânia Toledo de-
dc.contributor.authorNagem, Tanus Jorge-
dc.date.accessioned2017-06-19T14:32:55Z-
dc.date.available2017-06-19T14:32:55Z-
dc.date.issued2009-
dc.identifier.citationVIEIRA, F. T. et al. Spectroscopic investigation of organotin (IV) derivatives of 7-epiclusianone: a preliminary in vitro antitumor evaluation of HN-5 human carcinoma cell. Main Group Metal Chemistry, v. 32, p. 235-246, 2009. Disponível em: <https://www.degruyter.com/view/j/mgmc.2009.32.5/mgmc.2009.32.5.235/mgmc.2009.32.5.235.xml>. Acesso em: 20 mai. 2017.pt_BR
dc.identifier.issn2191-0219-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7981-
dc.description.abstractA series of organotin(IV) compounds have been prepared by reaction with 7-epiclusianone (Epi), a natural product extracted from fruits of Rheedia gardneriana. This compound has an interesting motif with several coordinating sites for metal-ligand bond formation, and in solution, it shows a keto-enol tautomerism. The NMR of the organotin(IV) derivatives has revealed intramolecular hydrogen bonding, indicating that the keto-enol tautomerism of 7-epiclusianone is not involved upon coordination of those, but the absence of this bonding type in the case of the SnCl4 derivative suggests a strong interaction. The Mössbauer spectroscopy has revealed five- and six-fold coordination for the organotin(IV) and SnCL» derivatives in the solid state. However, in solution all tin complexes have six-fold coordination, as shown by "9Sn NMR. The overall data point out that the organotin(IV) precursors SnClxPri4_x (x = 1, 2) are weakly bonded to the 7- epiclusianone, except the SnC^. Bioassay in vitro of the substance test [SnClPh3(£/7/)] (1) has been investigated using two epithelial cells: normal MDCK from canine kidney, and IIN-5 from a human carcinoma of the tongue. The results clearly demonstrate that the time for cellular reproduction has been reduced in the presence of the substance test.pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subject7-epiclusianonept_BR
dc.subjectOrganotinpt_BR
dc.subjectCarcinomapt_BR
dc.subjectSpectroscopypt_BR
dc.titleSpectroscopic investigation of organotin (IV) derivatives of 7-epiclusianone : a preliminary in vitro antitumor evaluation of HN-5 human carcinoma cell.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.identifier.uri2https://www.degruyter.com/view/j/mgmc.2009.32.5/mgmc.2009.32.5.235/mgmc.2009.32.5.235.xmlpt_BR
dc.identifier.doihttps://doi.org/10.1515/MGMC.2009.32.5.235-
Appears in Collections:DEQUI - Artigos publicados em periódicos

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