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Title: Time course of inflammation, oxidative stress and tissue damage induced by hyperoxia in mouse lungs.
Authors: Nagato, Akinori Cardozo
Bezerra, Frank Silva
Lanzetti, Manuella
Lopes, Alan de Aguiar
Silva, Marco Aurélio dos Santos
Porto, Luís Cristovão de Moraes Sobrino
Valença, Samuel dos Santos
Issue Date: 2012
Citation: NAGATO, A. C. et al. Time course of inflammation, oxidative stress and tissue damage induced by hyperoxia in mouse lungs. International Journal of Experimental Pathology, v. 93, p. 269-278, 2012. Disponível em: <>. Acesso em: 19 fev. 2017.
Abstract: In this study our aim was to investigate the time courses of inflammation, oxidative stress and tissue damage after hyperoxia in the mouse lung. Groups of BALB⁄ c mice were exposed to 100% oxygen in a chamber for 12, 24 or 48 h. The controls were subjected to normoxia. The results showed that IL-6 increased progressively after 12 (P < 0.001) and 24 h (P < 0.001) of hyperoxia with a reduction at 48 h (P < 0.01), whereas TNF-a increased after 24 (P < 0.001) and 48 h (P < 0.001). The number of macrophages increased after 24 h (P < 0.001), whereas the number of neutrophils increased after 24 h (P < 0.01) and 48 h (P < 0.001). Superoxide dismutase activity decreased in all groups exposed to hyperoxia (P < 0.01). Catalase activity increased only at 48 h (P < 0.001). The reduced glutathione ⁄ oxidized glutathione ratio decreased after 12 h (P < 0.01) and 24 h (P < 0.05). Histological evidence of lung injury was observed at 24 and 48 h. This study shows that hyperoxia initially causes an inflammatory response at 12 h, resulting in inflammation associated with the oxidative response at 24 h and culminating in histological damage at 48 h. Knowledge of the time course of inflammation and oxidative stress prior to histological evidence of acute lung injury can improve the safety of oxygen therapy in patients.
ISSN: 1365-2613
Appears in Collections:DECBI - Artigos publicados em periódicos

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