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Título: | Polymorphic screen and drug–excipient compatibility studies of the antichagasic benznidazole. |
Autor(es): | Maximiano, Flávia Pires Novack, Kátia Monteiro Bahia, Maria Terezinha Barreto, Lívia Cristina Lira de Sá Cunha Filho, Marcílio Sérgio Soares da |
Palavras-chave: | Benznidazole Compatibility Differential scanning calorimetry Fourier transform infrared spectroscopy |
Data do documento: | 2011 |
Referência: | MAXIMINIANO, F. P. et al. Polymorphic screen and drug–excipient compatibility studies of the antichagasic benznidazole. Journal of Thermal Analysis and Calorimetry, v. 106, p. 819-824, 2011. Disponível em: <https://link.springer.com/article/10.1007/s10973-011-1371-6>. Acesso em: 20 mai. 2017. |
Resumo: | The purpose of this study was to investigate the polymorphism and compatibility of benznidazole (BNZ), a drug used in the treatment of Chagas disease. This drug was subjected to a polymorphic screen using a number of solvents and precipitation procedures to explore the possible existence of different crystal structures of BNZ. The compatibility of BNZ with selected pharmaceutical excipients was evaluated in binary mixtures, in a ratio of 1:1 (w/w). These results were then analyzed with a variety of techniques, including differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray powder diffractometry. No polymorphic forms of BNZ were detected despite some observed changes in the DSC profile. The thermal data indicate interaction of the drug with excipients hydroxyethylcellulose, polyethylene glycol, and hydroxypropyl-b-cyclodextrin. Additional studies using infrared spectroscopy confirm the incompatibility of BNZ with only the polyethylene glycol. This excipient should not be used in the development of solid dosage forms containing BNZ. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7900 |
Link para o artigo: | https://link.springer.com/article/10.1007/s10973-011-1371-6 |
DOI: | https://doi.org/10.1007/s10973-011-1371-6 |
ISSN: | 1588-2926 |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_PolymorphicScreenDrug.pdf Restricted Access | 395,5 kB | Adobe PDF | Visualizar/Abrir |
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