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http://www.repositorio.ufop.br/jspui/handle/123456789/7882
Título: | Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. |
Autor(es): | Gomes, Aline Alves Lara Damasceno, Dênis Derly Pires, Rita Gomes Wanderley Gros, Robert Gomes, Enéas Ricardo de Morais Gavioli, Mariana Lima, Ricardo de Freitas Guimarães, Diogo Aparecido da Silva Lima, Patrícia Maria d'Almeida Bueno Júnior, Carlos Roberto Vasconcelos, Anilton Cesar Campos, Danilo Roman Menezes, Cristiane Alves da Silva Sirvente, Raquel de Assis Salemi, Vera Maria Cury Mady, Charles Caron, Marc G. Ferreira, Anderson José Brum, Patricia Chakur Resende, Rodrigo Ribeiro Cruz, Jader dos Santos Gomez, Marcus Vinicius Prado, Vânia Ferreira Almeida, Alvair Pinto de Prado, Marco Antônio Maximo Fonseca, Silvia Carolina Guatimosim |
Data do documento: | 2010 |
Referência: | GOMES, A. A. L. G. et al. Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. Molecular and Cellular Biology, v. 30, p. 1746-1756, 2010. Disponível em: <http://mcb.asm.org/content/30/7/1746.full>. Acesso em: 19 fev. 2017. |
Resumo: | Overwhelming evidence supports the importance of the sympathetic nervous system in heart failure. In contrast, much less is known about the role of failing cholinergic neurotransmission in cardiac disease. By using a unique genetically modified mouse line with reduced expression of the vesicular acetylcholine transporter (VAChT) and consequently decreased release of acetylcholine, we investigated the consequences of altered cholinergic tone for cardiac function. M-mode echocardiography, hemodynamic experiments, analysis of isolated perfused hearts, and measurements of cardiomyocyte contraction indicated that VAChT mutant mice have decreased left ventricle function associated with altered calcium handling. Gene expression was analyzed by quantitative reverse transcriptase PCR and Western blotting, and the results indicated that VAChT mutant mice have profound cardiac remodeling and reactivation of the fetal gene program. This phenotype was attributable to reduced cholinergic tone, since administration of the cholinesterase inhibitor pyridostigmine for 2 weeks reversed the cardiac phenotype in mutant mice. Our findings provide direct evidence that decreased cholinergic neurotransmission and underlying autonomic imbalance cause plastic alterations that contribute to heart dysfunction. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7882 |
Link para o artigo: | https://mcb.asm.org/content/30/7/1746.full |
DOI: | https://doi.org/10.1128/MCB.00996-09 |
ISSN: | 1098-5549 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_DysautonomiaDueReduced.pdf Restricted Access | 1,54 MB | Adobe PDF | Visualizar/Abrir |
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