Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7859
Title: Effects of Trypanosoma cruzi infection on myocardial morphology, single cardiomyocyte contractile function and exercise tolerance in rats.
Authors: Novaes, Rômulo Dias
Penitente, Arlete Rita
Gonçalves, Reggiani Vilela
Silva, André Talvani Pedrosa da
Neves, Clóvis Andrade
Maldonado, Izabel Regina dos Santos Costa
Natali, Antônio José
Keywords: Cellular contractility
Myocytes
Physical capacity
Issue Date: 2011
Citation: NOVAES, R. D. et al. Effects of Trypanosoma cruzi infection on myocardial morphology, single cardiomyocyte contractile function and exercise tolerance in rats. International Journal of Experimental Pathology, v. 92, p. 299-307, 2011. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2011.00781.x/abstract>. Acesso em: 19 fev. 2017.
Abstract: The aim of this study was to investigate the effects of Trypanosoma cruzi (T. cruzi) infection on myocardial morphology, single cardiomyocyte contractile function and exercise tolerance in rats. Adult Wistar rats were randomized into control (n = 14) and infected (n = 14) groups. Infected animals were inoculated with T. cruzi Y strain (300,000 trypomastigotes ⁄ 50 g body weight). After 9 weeks, the animals were subjected to a treadmill running protocol. Then, the right atrium (RA) and left ventricle (LV) were removed for morphological and cell contractile evaluation. The infected animals exhibited a significant reduction in distance travelled, total time to fatigue and workload. In addition, these animals had hypertrophy, increased myocardial cellularity, and an increase in the proportion of collagen and blood vessels. RA and LV myocytes from infected animals showed marked contractile dysfunction under basal conditions and a reduced contractile response to b-adrenergic stimulation. The workload of infected animals was correlated closely with the amplitude of cell shortening of RA and LV myocytes. T. cruzi infection influenced the myocardial morphology and the mechanical properties of RA and LV single myocytes negatively and reduced exercise tolerance. Single cardiomyocyte contractile dysfunction could constitute an additional mechanism of cardiac impairment and reduced exercise tolerance in this infection.
URI: http://www.repositorio.ufop.br/handle/123456789/7859
metadata.dc.identifier.uri2: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2011.00781.x/abstract
ISSN: 13652613
Appears in Collections:DECBI - Artigos publicados em periódicos

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