Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7858
Title: Low doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs.
Authors: Melo, Lilian
Caldas, Ivo Santana
Azevedo, Maíra Araújo
Gonçalves, Karolina Ribeiro
Nascimento, Alvaro Fernando da Silva do
Figueiredo, Vivian Paulino
Diniz, Lívia de Figueiredo
Lima, Wanderson Geraldo de
Torres, Rosália Morais
Bahia, Maria Terezinha
Silva, André Talvani Pedrosa da
Issue Date: 2011
Citation: MELO, L. et al. Low doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs. The American Journal of Tropical Medicine and Hygiene, v. 84, p. 325-331, 2011. Disponível em: <http://www.ajtmh.org/content/84/2/325>. Acesso em: 19 fev. 2017.
Abstract: Chagas cardiomyopathy remodeling is based on the presence of Trypanosoma cruzi in heart tissue and on the complex inflammatory response leading to a myocardium fibrosis and alterations in conductive and functional heart parameters. This study aims to evaluate Simvastatin on the inflammatory response and heart functionality using dogs infected with Y strain of T. cruzi . Animals were treated daily with Simvastatin (20 mg) for 6 months and submitted to clinical and immunopathological evaluations. Simvastatin reduced heart expression and serum levels of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) but not interleukin-10 (IL-10), possibly favoring blood parasitism but reducing inflammation and fibrosis in the left ventricle and right atrium. Simvastatin also ameliorated ejection fraction, diastolic diameter, and mass index of the left ventricle 6 months after infection. This study suggests that more investigation should be performed on the use of statins as a prophylactic therapy against cardiac remodeling because of their effects on modifying immune response and benefiting functional parameters in dogs with T. cruzi -induced ventricular dysfunctions.
URI: http://www.repositorio.ufop.br/handle/123456789/7858
metadata.dc.identifier.uri2: http://www.ajtmh.org/content/84/2/325
ISSN: 14761645
Appears in Collections:DECBI - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_LowDosesSimvastatin.pdf1,41 MBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.