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|Title:||A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study.|
|Authors:||Freitas, Renata Nascimento de|
Wareham, Nick J.
Bingham, Sheila A.
|Citation:||FREITAS, R. N. de et al. A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. European Journal of Cardiovascular Prevention & Rehabilitation, v. 8104, p. 765–772, 2010. Disponível em: <http://journals.sagepub.com/doi/pdf/10.1097/HJR.0b013e328330be77>. Acesso em: 21 mar. 2017.|
|Abstract:||The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl- coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available. Genotype frequencies and allele distributions for 23 011 participants were: TT 95·65 %, TG 4·29% and GG 0·06 %; T 97·8% and G 2·2 %. In regression analyses, the TG þ GG group showed a significant positive relationship between TAG and SFA intake (þ0·11 (95% CI 0·02, 0·20) mmol TAG/l; P¼0·017; per 3% SFA energy increase) while the TT individuals showed no change in the TAG levels related to SFA intake (20·0007 (95% CI 20·02, 0·02) mmol TAG/l; P¼0·99). TG þ GG individuals showed an inverse relationship between TAG and fibre intake higher (20·14 (95% CI 20·22, 20·05) mmol TAG/l than the TT group (20·04 (95% CI 20·06, 20·02) mmol TAG/l). In both cases the respective coefficient regressions of TAG were different between the genotype groups (Z ¼ 2·27, P¼0·023 for SFA intake; Z ¼ 2·19, P¼0·029 for fibre intake). Individuals carrying the G allele may show a greater response in lower TAG levels with reduced SFA intake and increased fibre intake compared with those homozygous for the T allele. The effectiveness of different dietary interventions to control serum lipids may vary according to HMGCR genotype.|
|metadata.dc.rights.license:||O periódico British Journal of Nutrition permite o arquivamento da versão PDF do editor em repositórios de acesso aberto. Fonte: Sherpa/Romeo <http://www.sherpa.ac.uk/romeo/search.php>. Acesso em: 16 mar. 2017.|
|Appears in Collections:||DENCS - Artigos publicados em periódicos|
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