Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7655
Title: Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla.
Authors: Alzamora, Andréia Carvalho
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Keywords: Renin-angiotensin system
Arterial pressure
Issue Date: 2006
Citation: ALZAMORA, A. C.; SANTOS, R. A. S.; SANTOS, M. J. C. Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla. Regulatory, Integrative and Comparative Physiology, v. 290, n.00852, p. R1027-R1034, 2006. Disponível em: <http://ajpregu.physiology.org/content/290/4/R1027>. Acesso em: 19 fev. 2017.
Abstract: Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol 290: R1027–R1034, 2006. First published November 23, 2005; doi:10.1152/ajpregu.00852.2004.—We determined the effect of microinjection of ANG-(1–7) and ANG II into two key regions of the medulla that control the circulation [rostral and caudal ventrolateral medulla (RVLM and CVLM, respectively)] on baroreflex control of heart rate (HR) in anesthetized rats. Reflex bradycardia and tachycardia were induced by increases and decreases in mean arterial pressure produced by intravenous phenylephrine and sodium nitroprusside, respectively. The pressor effects of ANG-(1–7) and ANG II (25 pmol) after RVLM microinjection (11 0.8 and 10 2 mmHg, respectively) were not accompanied by consistent changes in HR. In addition, RVLM microinjection of these angiotensin peptides did not alter the bradycardic or tachycardic component of the baroreflex. CVLM microinjections of ANG-(1–7) and ANG II produced hypotension ( 11 1.5 and 11 1.9 mmHg, respectively) that was similarly not accompanied by significant changes in HR. However, CVLM microinjections of angiotensins induced differential changes in the baroreflex control of HR. ANG-(1–7) attenuated the baroreflex bradycardia (0.26 0.06 ms/mmHg vs. 0.42 0.08 ms/mmHg before treatment) and facilitated the baroreflex tachycardia (0.86 0.19 ms/mmHg vs. 0.42 0.10 ms/mmHg before treatment); ANG II produced the opposite effect, attenuating baroreflex tachycardia (0.09 0.06 ms/mmHg vs. 0.31 0.07 ms/mmHg before treatment) and facilitating the baroreflex bradycardia (0.67 0.16 ms/mmHg vs. 0.41 0.05 ms/mmHg before treatment). The modulatory effect of ANG II and ANG-(1–7) on baroreflex sensitivity was completely abolished by peripheral administration of methylatropine. These results suggest that ANG II and ANG-(1–7) at the CVLM produce a differential modulation of the baroreflex control of HR, probably through distinct effects on the parasympathetic drive to the heart.
URI: http://www.repositorio.ufop.br/handle/123456789/7655
metadata.dc.identifier.uri2: http://ajpregu.physiology.org/content/290/4/R1027
ISSN: 15221490
Appears in Collections:DECBI - Artigos publicados em periódicos

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