Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/7646
Registro completo de metadados
Campo Dublin Core | Valor | Idioma |
---|---|---|
dc.contributor.author | Santos, Robson Augusto Souza dos | - |
dc.contributor.author | Silva, Ana Cristina Simões e | - |
dc.contributor.author | Maric, Christine | - |
dc.contributor.author | Rabelo, Denise Maria Rover da Silva | - |
dc.contributor.author | Machado, Raquel do Pilar | - |
dc.contributor.author | Buhr, Insa de | - |
dc.contributor.author | Walther, Silvia Heringer | - |
dc.contributor.author | Pinheiro, Sérgio Veloso Brant | - |
dc.contributor.author | Lopes, Miriam Teresa Paz | - |
dc.contributor.author | Bader, Michael | - |
dc.contributor.author | Mendes, Elizabeth Pereira | - |
dc.contributor.author | Lemos, Virgina Soares | - |
dc.contributor.author | Santos, Maria José Campagnole dos | - |
dc.contributor.author | Schultheiss, Heinz-Peter | - |
dc.contributor.author | Speth, Robert | - |
dc.contributor.author | Walther, Thomas | - |
dc.date.accessioned | 2017-04-27T13:01:49Z | - |
dc.date.available | 2017-04-27T13:01:49Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | SANTOS, R. A. S. et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proceedings National Academy Science, v. 100, n.14, p. 8258-8263, 2003. Disponível em: <http://www.pnas.org/content/100/14/8258.long>. Acesso em: 23 fev. 2017. | pt_BR |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/7646 | - |
dc.description.abstract | The renin–angiotensin system plays a critical role in blood pressure control and body fluid and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang III [Ang-(2–8)], Ang IV [Ang-(3–8)], and Ang-(1–7) may also have important biological activities. Ang-(1–7) has become an angiotensin of interest in the past few years, because its cardiovascular and baroreflex actions counteract those of Ang II. Unique angiotensin-binding sites specific for this heptapeptide and studies with a selective Ang-(1–7) antagonist indicated the existence of a distinct Ang-(1–7) receptor. We demonstrate that genetic deletion of the G proteincoupled receptor encoded by the Mas protooncogene abolishes the binding of Ang-(1–7) to mouse kidneys. Accordingly, Mas-deficient mice completely lack the antidiuretic action of Ang-(1–7) after an acute water load. Ang-(1–7) binds to Mas-transfected cells and elicits arachidonic acid release. Furthermore, Mas-deficient aortas lose their Ang-(1–7)-induced relaxation response. Collectively, these findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Binding | pt_BR |
dc.subject | Mas protooncogene | pt_BR |
dc.subject | Renin angiotensin system | pt_BR |
dc.title | Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.identifier.uri2 | http://www.pnas.org/content/100/14/8258.long | pt_BR |
dc.identifier.doi | https://doi.org/10.1073/pnas.1432869100 | - |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_AngiotensinEndogenousLigand.pdf Restricted Access | 637,29 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.