Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7646
Title: Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Authors: Santos, Robson Augusto Souza dos
Silva, Ana Cristina Simões e
Maric, Christine
Rabelo, Denise Maria Rover da Silva
Machado, Raquel do Pilar
Buhr, Insa de
Walther, Silvia Heringer
Pinheiro, Sérgio Veloso Brant
Lopes, Miriam Teresa Paz
Bader, Michael
Mendes, Elizabeth Pereira
Lemos, Virgina Soares
Santos, Maria José Campagnole dos
Schultheiss, Heinz-Peter
Speth, Robert
Walther, Thomas
Keywords: Binding
Mas protooncogene
Renin angiotensin system
Issue Date: 2003
Citation: SANTOS, R. A. S. et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proceedings National Academy Science, v. 100, n.14, p. 8258-8263, 2003. Disponível em: <http://www.pnas.org/content/100/14/8258.long>. Acesso em: 23 fev. 2017.
Abstract: The renin–angiotensin system plays a critical role in blood pressure control and body fluid and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang III [Ang-(2–8)], Ang IV [Ang-(3–8)], and Ang-(1–7) may also have important biological activities. Ang-(1–7) has become an angiotensin of interest in the past few years, because its cardiovascular and baroreflex actions counteract those of Ang II. Unique angiotensin-binding sites specific for this heptapeptide and studies with a selective Ang-(1–7) antagonist indicated the existence of a distinct Ang-(1–7) receptor. We demonstrate that genetic deletion of the G proteincoupled receptor encoded by the Mas protooncogene abolishes the binding of Ang-(1–7) to mouse kidneys. Accordingly, Mas-deficient mice completely lack the antidiuretic action of Ang-(1–7) after an acute water load. Ang-(1–7) binds to Mas-transfected cells and elicits arachidonic acid release. Furthermore, Mas-deficient aortas lose their Ang-(1–7)-induced relaxation response. Collectively, these findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide.
URI: http://www.repositorio.ufop.br/handle/123456789/7646
metadata.dc.identifier.uri2: http://www.pnas.org/content/100/14/8258.long
ISSN: 10916490
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