Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/762
Title: Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
Authors: Câmara, Diógenes Vadim
Lemos, Virgínia Soares
Santos, Marcelo Henrique dos
Nagem, Tanus Jorge
Côrtes, Steyner de França
Keywords: Xanthone
Protein kinase C
Resistance artery
Vasodilatation
Issue Date: 2010
Citation: CÂMARA, D. V. et al. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine, v. 17, n. 8-9, p. 690-692, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S094471130900333X>. Acesso em: 22 maio 2012.
Abstract: Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.
URI: http://www.repositorio.ufop.br/handle/123456789/762
ISSN: 09447113
metadata.dc.rights.license: O Periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3490231006877.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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