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dc.contributor.authorCorrêa, Paulo Roberto Ceridóreo-
dc.contributor.authorMiranda, Roqueline Rodrigues Silva de-
dc.contributor.authorDuarte, Lucienir Pains-
dc.contributor.authorSilva, Grácia Divina de Fátima-
dc.contributor.authorVieira Filho, Sidney Augusto-
dc.contributor.authorOkuma, Adriana Akemi-
dc.contributor.authorCarazza, Fernando-
dc.contributor.authorDíaz, José Andrés Morgado-
dc.contributor.authorPinge Filho, Phileno-
dc.contributor.authorYamauchi, Lucy Megumi-
dc.contributor.authorNakamura, Celso Vataru-
dc.contributor.authorOgatta, Sueli Fumie Yamada-
dc.identifier.citationCORRÊA, P. R. C. et al. Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. Pathogens and Global Health, v. 106, p. 107, 2012. Disponível em: <>. Acesso em: 20 jan. 2017.pt_BR
dc.description.abstractWe report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl- 39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections.pt_BR
dc.titleAntimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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