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Title: A tetravalent dengue nanoparticle stimulates antibody production in mice.
Authors: Silva, Elisângela
Orsi, Mariana
Andrade, Ângela Leão
Domingues, Rosana Zacarias
Silva, Breno de Mello
Araújo, Helena de
Pimenta, Paulo Filemon Paolucci
Diamond, Michael
Rocha, Eliseu
Kroon, Erna Geessien
Malaquias, Luiz Cosme Cotta
Coelho, Luiz
Keywords: Inactivated Dengue vírus
Humoral response
Issue Date: 2012
Citation: SILVA, E. F. et al. A tetravalent dengue nanoparticle stimulates antibody production in mice. Journal of Nanobiotechnology, v. 10, p. 13, 2012. Disponível em: <> Acesso em: 19 fev. 2017.
Abstract: Dengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndrome. Currently, there are no licensed vaccines or antiviral drugs to prevent or treat dengue infections. Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines.
ISSN: 1477-3155
metadata.dc.rights.license: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.
Appears in Collections:DECBI - Artigos publicados em periódicos

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