Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7333
Title: Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes.
Authors: Toledo, Max Jean de Ornelas
Bahia, Maria Terezinha
Veloso, Vanja Maria
Carneiro, Claudia Martins
Coelho, George Luiz Lins Machado
Alves, Cíntia Fontes
Martins, Helen Rodrigues
Cruz, Ruth Elizabeth
Tafuri, Washington Luiz
Lana, Marta de
Keywords: Experimental chemotherapy
Benznidazole
Itraconazole
Genetic groups
Issue Date: 2004
Citation: ORNELAS, M. J. de et al. Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes. Journal Of Antimicrobial Chemotherapy, v. 53, n. 6, p.1045-1053, 2004. Disponível em: <http://jac.oxfordjournals.org/content/53/6/1045.long>. Acesso em: 10 jan. 2017.
Abstract: The goal of this study was to verify the effect of specific treatment on parasitological and histopathological parameters in mice experimentally infected with different Trypanosoma cruzi clonal genotypes. Twenty cloned stocks were selected, representative of the whole phylogenetic diversity of the protozoan and belonging to the clonal genotypes 19 and 20 (T. cruzi I) and 39 and 32 (T. cruzi II). The stocks were inoculated in 40 BALB/c mice divided into four groups: (i) treated with benznidazole, (ii) treated with itraconazole and (iii and iv) untreated control groups (NT) for each drug, respectively. Seven parameters related to parasitaemia curves and histopathological lesions were analysed. Four during the acute phase (AP) and three during both the AP and chronic phase (CP) of infection. Statistical comparison between benznidazole-treated and NT groups for the biological parameters showed significant differences for all genotypes. Benznidazole treatment led to lower patent period, maximum of parasitaemia, day of maximum parasitaemia and area under the parasitaemia curve for all genotypes analysed. Percentage of positive haemoculture during AP and CP was lower for genotypes 19 and 32. Tissue parasitism (TP) and inflammatory process (IP) during AP were lower for genotypes 19 and 32, respectively. In general, itraconazole treatment induced a smaller reduction in these same parameters between treated and NT animals in relation to benznidazole treatment. Our results indicate that phylogenetic divergence among T. cruzi clonal genotypes must be taken in account in chemotherapy and studies dealing with all aspects of the parasite and the disease.
URI: http://www.repositorio.ufop.br/handle/123456789/7333
metadata.dc.identifier.uri2: http://jac.oxfordjournals.org/content/53/6/1045.long
ISSN: 14602091
Appears in Collections:DEFAR - Artigos publicados em periódicos

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