Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7323
Title: Trypanosoma cruzi high infectivity in vitro is related to cardiac lesions during long-term infection in beagle dogs.
Authors: Guedes, Paulo Marcos da Matta
Veloso, Vanja Maria
Caliari, Marcelo Vidigal
Carneiro, Claudia Martins
Souza, Sheler Martins de
Lana, Marta de
Chiari, Egler
Bahia, Maria Terezinha
Galvão, Lúcia Maria da Cunha
Keywords: Chagas disease
Antibodies
Issue Date: 2007
Citation: GUEDES, P. M. da M. et al. Trypanosoma cruzi high infectivity in vitro is related to cardiac lesions during long-term infection in beagle dogs. Memórias do Instituto Oswaldo Cruz, v. 102, p.141-147, 2007. Disponível em: <http://www.scielo.br/pdf/mioc/v102n2/5685.pdf>. Acesso em: 10 jan. 2017.
Abstract: Trypanosoma cruzi is a hemoflagelate parasite associated with heart dysfunctions causing serious problems in Central and South America. Beagle dogs develop the symptoms of Chagas disease in humans, and could be an important experimental model for better understanding the immunopathogenic mechanisms involved in the chagasic infection. In the present study we investigated the relation among biological factors inherent to the parasite (trypomastigote polymorphism and in vitro infectivity) and immunoglobulin production, inflammation, and fibrosis in the heart of Beagle dogs infected with either T. cruzi Y or Berenice-78 strains. In vitro infectivity of Vero cells as well as the extension of cardiac lesions in infected Beagle was higher for Y strain when compared to Berenice-78 strain. These data suggested that in vitro infectivity assays may correlate with pathogenicity in vivo. In fact, animals infected with Y strain, which shows prevalence of slender forms and high infectivity in vitro, presented cardiomegaly, inflammation, and fibrosis in heart area. Concerning the immunoglobulin production, no statistically significant difference was observed for IgA, IgM or IgG levels among T. cruzi infected animals. However, IgA together IgM levels have shown to be a good marker for the acute phase of Chagas disease.
URI: http://www.repositorio.ufop.br/handle/123456789/7323
ISSN: 00740276
metadata.dc.rights.license: O periódico, Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12/12/2013.
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