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Title: Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease.
Authors: Francisco, Amanda Fortes
Vieira, Paula Melo de Abreu
Arantes, Jerusa Marilda
Silva, Maísa
Pedrosa, Maria Lúcia
Santos, Silvana Maria Elói
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Araújo, Márcio Sobreira Silva
Keywords: Oxidative stress
Trypanosoma cruzi
Issue Date: 2010
Citation: FRANCISCO, A. F. et al. Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. Redox Report, v. 15, p.185-190, 2010. Disponível em: <>. Acesso em: 10 jan. 2017.
Abstract: Oxidative stress is common in inflammatory processes associated with many diseases including Chagas’ disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant system in order to provide an overview of the mechanism of action of the iron chelator desferrioxamine (DFO). The study population comprised 48 male Swiss mice, half of which were treated daily by intraperitoneal injection of DFO over a 35-day period, while half were administered sterile water in a similar manner. On the 14th day of the experiment, 12 DFO-treated mice and an equal number of untreated mice were experimentally infected with Trypanosoma cruzi. Serum concentrations of nitric oxide and superoxide dismutase and hepatic levels of total glutathione, thiobarbituric acid reactive species and protein carbonyl, were determined on days 0, 7, 14 and 21 post-infection. The results obtained revealed that DFO enhances antioxidant activity in the host but also increases oxidative stress, indicating that the mode of action of the drug involves a positive contribution to the host together with an effect that is not beneficial to the parasite.
ISSN: 1351-0002
Appears in Collections:DEFAR - Artigos publicados em periódicos

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