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Title: Splenectomy increases mortality in murine Trypanosoma cruzi infection.
Authors: Maioli, Tatiani Uceli
Assis, Frankcinéia Aparecida de
Vieira, Paula Melo de Abreu
Borelli, Primavera
Santiago, Helton da Costa
Alves, Ricardo José
Romanha, Alvaro José
Carneiro, Cláudia Martins
Faria, Ana Maria Caetano de
Issue Date: 2011
Citation: MAIOLI, T. U. et al. Splenectomy increases mortality in murine Trypanosoma cruzi infection. Scandinavian Journal of Immunology, v. 73, p.36-45, 2011. Disponível em: <>. Acesso em: 10 jan. 2017.
Abstract: The spleen is a secondary lymphoid organ that harbours a variety of cells such as T and B lymphocytes and antigen-presenting cells important to immune response development. In this study, we evaluated the impact of spleen removal in the immune response to experimental Trypanosoma cruzi infection. C57BL/6 mice were infected with Y strain of the parasite and infection was followed daily. Mice that underwent splenectomy had fewer parasites in peripheral blood at the peak of infection; however, mortality was increased. Histological analysis of heart and liver tissues revealed an increased number of parasites and inflammatory infiltrates at these sites. Spleen removal was associated with reduction in IFN-γ and TNF-α production during infection as well as with a decrease in specific antibody secretion. Haematological disorders were also detected. Splenectomized mice exhibited severe anaemia and decreased bone marrow cell numbers. Our results indicate that spleen integrity is critical in T. cruzi infection for the immune response against the parasite, as well as for the control of bone marrow haematological function.
ISSN:  1365-3083
Appears in Collections:DEFAR - Artigos publicados em periódicos
DEFAR - Artigos publicados em periódicos

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