Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7272
Title: Antibodies from dogs with canine visceral leishmaniasis (CVL) recognise two proteins from the saliva of lutzomyia longipalpis.
Authors: Bahia, Diana
Gontijo, Nelder de Figueiredo
León, Ileana Rodríguez
Perales, Jonas
Pereira, Marcos Horácio
Oliveira, Guilherme Corrêa de
Oliveira, Rodrigo Corrêa de
Reis, Alexandre Barbosa
Issue Date: 2007
Citation: BAHIA, D. et al. Antibodies from dogs with canine visceral leishmaniasis (CVL) recognise two proteins from the saliva of lutzomyia longipalpis. Parasitology Research, v. 100, p.449-454, 2007. Disponível em: <http://link.springer.com/article/10.1007/s00436-006-0307-8>. Acesso em: 10 out. 2016.
Abstract: The saliva of the sand fly Lutzomyia longipalpis, a major vector of Leishmania, exhibits pharmacological and immunomodulatory activities that may facilitate entry and establishment of parasites into the vertebrate host. Salivary gland components of the sand fly are, therefore, potential candidates in the development of a vaccine against human leishmaniasis. With the objective of identifying sand fly saliva proteins that could be used to immunise animals against canine visceral leishmaniasis, we have evaluated anti-saliva antibody reactivity using serum samples collected from dogs naturally infected with Leishmania chagasi. Two proteins with molecular weights of 28.6 and 47.3 kDa were recognised by dog antibodies in Western blot assays. Protein bands were excised from an SDS-PAGE gel and the sequences determined by mass spectrometry. The proteins were identified as LuLo-D7 and Lulo YELLOW, respectively. The significance of these findings in the context of the development of multicomponent vaccination experiments is discussed.
URI: http://www.repositorio.ufop.br/handle/123456789/7272
metadata.dc.identifier.uri2: http://link.springer.com/article/10.1007/s00436-006-0307-8
ISSN: 14321955
Appears in Collections:DEFAR - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_AntibodiesDogCanine.pdf201,44 kBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.