Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7259
Title: Immunotherapy and immunochemotherapy in visceral leishmaniasis : promising treatments for this neglected disease.
Authors: Roatt, Bruno Mendes
Soares, Rodrigo Dian de Oliveira Aguiar
Vital, Wendel Coura
Ker, Henrique Gama
Moreira, Nádia das Dores
Souza, Juliana Vitoriano de
Giunchetti, Rodolfo Cordeiro
Carneiro, Cláudia Martins
Reis, Alexandre Barbosa
Keywords: Immunology
Leishmania infantum
Leishmania donovani
Issue Date: 2014
Citation: ROATT, B. M. et al. Immunotherapy and immunochemotherapy in visceral leishmaniasis : promising treatments for this neglected disease. Frontiers In Immunology, v. 5, p.272 1- 272 12, 2014. Disponível em: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055865/>. Acesso em: 10 out. 2016
Abstract: Leishmaniasis has several clinical forms: self-healing or chronic cutaneous leishmaniasis or post-kala-azar dermal leishmaniasis; mucosal leishmaniasis; visceral leishmaniasis (VL), which is fatal if left untreated.The epidemiology and clinical features of VL vary greatly due to the interaction of multiple factors including parasite strains, vectors, host genetics, and the environment. Human immunodeficiency virus infection augments the severity of VL increasing the risk of developing active disease by 100–2320 times. An effective vaccine for humans is not yet available. Resistance to chemotherapy is a growing problem in many regions, and the costs associated with drug identification and development, make commercial production for leishmaniasis, unattractive.The toxicity of currently drugs, their long treatment course, and limited efficacy are significant concerns. For cutaneous disease, many studies have shown promising results with immunotherapy/immunochemotherapy, aimed to modulate and activate the immune response to obtain a therapeutic cure. Nowadays, the focus of many groups centers on treating canine VL by using vaccines and immunomodulators with or without chemotherapy. In human disease, the use of cytokines like interferon-g associated with pentavalent antimonials demonstrated promising results in patients that did not respond to conventional treatment. In mice, immunomodulation based on monoclonal antibodies to remove endogenous immunosuppressive cytokines (interleukin-10) or block their receptors, antigen-pulsed syngeneic dendritic cells, or biological products like Pam3Cys (TLR ligand) has already been shown as a prospective treatment of the disease. This review addresses VL treatment, particularly immunotherapy and/or immunochemotherapy as an alternative to conventional drug treatment in experimental models, canine VL, and human disease.
URI: http://www.repositorio.ufop.br/handle/123456789/7259
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. fonte: Frontiers in Immunology <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055865/> Acesso em 10 nov 2016.
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