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Title: Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.
Authors: Benedicto, Augusto Vieira Lima
Correa, Rodrigo de Souza
Graminha, Angelica Ellen
Kuznetsov, Aleksey Evgenyevich
Ellena, Javier Alcides
Pavan, Fernando Rogério
Leite, Clarice Queico Fujimura
Batista, Alzir Azevedo
Keywords: Ruthenium complexes
Diphosphine ligand
Cytotoxity - tuberculosis
Issue Date: 2016
Citation: BENEDICTO, A. V. L. et al. Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes: the role of the non-coordinated N-atom. Journal of the Brazilian Chemical Society, v. 27, p. 30-40, 2016. Disponível em: <>. Acesso em: 26 set. 2016.
Abstract: The [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1’-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA.
ISSN: 1678-4790
metadata.dc.rights.license: Todo o conteúdo do periódico Journal of the Brazilian Chemical Society, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Journal of the Brazilian Chemical Society <>. Acesso em: 23 ago. 2019.
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