Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7034
Title: Ruthenium(II) complexes with hydroxypyridinecarboxylates : screening potential metallodrugs against Mycobacterium tuberculosis.
Authors: Barbosa, Marília Imaculada Frazão
Correa, Rodrigo de Souza
Pozzi, Lucas Vinícius dos Santos
Pavan, Fernando Rogério
Leite, Clarice Queico Fujimura
Ellena, Javier Alcides
Machado, Sérgio de Paula
Poelhsitz, Gustavo Von
Batista, Alzir Azevedo
Keywords: Mycobacterium tuberculosis
Ruthenium(II) complexes
Cytotoxicity
Metallodrugs
Hydroxypyridinecarboxylates
Issue Date: 2015
Citation: BARBOSA. M. I. F. et al. Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis. Polyhedron, v. 85, p. 376-382, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538714005889>. Acesso em: 26 set. 2016.
Abstract: Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index.
URI: http://www.repositorio.ufop.br/handle/123456789/7034
metadata.dc.identifier.doi: https://doi.org/10.1016/j.poly.2014.08.057
ISSN: 02775387
metadata.dc.rights.license: O periódico Polyhedron concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611410935.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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