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Título: | Ruthenium(II) complexes with hydroxypyridinecarboxylates : screening potential metallodrugs against Mycobacterium tuberculosis. |
Autor(es): | Barbosa, Marília Imaculada Frazão Correa, Rodrigo de Souza Pozzi, Lucas Vinícius dos Santos Pavan, Fernando Rogério Leite, Clarice Queico Fujimura Ellena, Javier Alcides Machado, Sérgio de Paula Poelhsitz, Gustavo Von Batista, Alzir Azevedo |
Palavras-chave: | Mycobacterium tuberculosis Ruthenium(II) complexes Cytotoxicity Metallodrugs Hydroxypyridinecarboxylates |
Data do documento: | 2015 |
Referência: | BARBOSA. M. I. F. et al. Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis. Polyhedron, v. 85, p. 376-382, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538714005889>. Acesso em: 26 set. 2016. |
Resumo: | Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7034 |
DOI: | https://doi.org/10.1016/j.poly.2014.08.057 |
ISSN: | 02775387 |
Licença: | O periódico Polyhedron concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611410935. |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
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Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_RutheniumComplexesHydroxypyridinecarboxilate.pdf | 1,03 MB | Adobe PDF | Visualizar/Abrir |
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