Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7033
Title: Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands : synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells.
Authors: Correa, Rodrigo de Souza
Oliveira, Katia Mara de
Delolo, Fábio Godoy
Alvarez Hernández, Anislay
Mocelo, Raúl
Plutin, Ana M.
Cominetti, Márcia Regina
Castellano, Eduardo Ernesto
Batista, Alzir Azevedo
Keywords: Acylthiourea ligands
Prostate cancer
Lung cancer
Issue Date: 2015
Citation: CORREA, R. de S. et al. Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands: synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells. Journal of Inorganic Biochemistry, v. 150, p. 63-71, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0162013415001026>. Acesso em: 26 set. 2016.
Abstract: Four ruthenium(II)-based complexeswith N-(acyl)-N′,N′-(disubstituted)thiourea derivatives (Th)were obtained. The compounds, with the general formula trans-[Ru(PPh3)2(Th)(bipy)]PF6, interact with bovine serum albumin (BSA) and DNA. BSA-binding constants, which were in the range of 3.3–6.5 × 104 M−1, and the thermodynamic parameters (ΔG, ΔH and ΔS), suggest spontaneous interactions with this protein by electrostatic forces due to the positive charge of the complexes. Also, binding constant by spectrophotometric DNA titration (Kb = 0.8–1.8 × 104 M−1) and viscosity studies indicate weak interactions between the complexes and DNA. Cytotoxicity assays against DU-145 (prostate cancer) and A549 (lung cancer) tumour cells revealed that the complexes are more active in tumour cells than in normal (L929) cells, and that they present high cytotoxicity (low IC50 values) compared with the reference metallodrug, cisplatin.
URI: http://www.repositorio.ufop.br/handle/123456789/7033
metadata.dc.identifier.doi: https://doi.org/10.1016/j.jinorgbio.2015.04.008
ISSN: 0162-0134
metadata.dc.rights.license: O periódico Journal of Inorganic Biochemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611287599.
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