Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7026
Title: Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy.
Authors: Sathyavathi, R.
Saha, Anushree
Soares, Jaqueline dos Santos
Spegazzini, Nicolas
McGee, Sasha
Dasari, Ramachandra Rao
Fitzmaurice, Maryann
Barman, Ishan
Issue Date: 2015
Citation: SATHYAVATHI, R. et al. Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy. Scientific Reports, v. 5, p. 9907, 2015. Disponível em: <https://www.nature.com/articles/srep09907>. Acesso em: 07 ago. 2016.
Abstract: Microcalcifications are an early mammographic sign of breast cancer and frequent target for stereotactic biopsy. Despite their indisputable value, microcalcifications, particularly of the type II variety that are comprised of calcium hydroxyapatite deposits, remain one of the least understood disease markers. Here we employed Raman spectroscopy to elucidate the relationship between pathogenicity of breast lesions in fresh biopsy cores and composition of type II microcalcifications. Using a chemometric model of chemical-morphological constituents, acquired Raman spectra were translated to characterize chemical makeup of the lesions. We find that increase in carbonate intercalation in the hydroxyapatite lattice can be reliably employed to differentiate benign from malignant lesions, with algorithms based only on carbonate and cytoplasmic protein content exhibiting excellent negative predictive value (93–98%). Our findings highlight the importance of calcium carbonate, an underrated constituent of microcalcifications, as a spectroscopic marker in breast pathology evaluation and pave the way for improved biopsy guidance.
URI: http://www.repositorio.ufop.br/handle/123456789/7026
metadata.dc.identifier.doi: https://doi.org/10.1038/srep09907
ISSN: 2045-2322
metadata.dc.rights.license: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Fonte: o próprio artigo.
Appears in Collections:DEFIS - Artigos publicados em periódicos

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