Use este identificador para citar ou linkar para este item: http://www.repositorio.ufop.br/handle/123456789/6693
Título: Rapid and efficient synthesis of α(1 – 2) mannobiosides.
Autor(es): Reina, José Juan
Maio, Antonio Di
Ramos Soriano, Javier
Figueiredo, Rute Cunha
Rojo Marcos, Francisco Javier
Data do documento: 2016
Referência: LÓPEZ MARTÍN, J. J. et al. Rapid and efficient synthesis of α(1 – 2) mannobiosides. Organic & Biomolecular Chemistry, v. 14, p. 2873-2882, 2016. Disponível em: <http://pubs.rsc.org/en/content/articlepdf/2016/ob/c6ob00083e>. Acesso em: 16 jun. 2016.
Resumo: α(1,2) mannobiosides with different substituents at the reducing end have been synthesized by a common strategy using benzoyls as the permanent protecting groups and an acetyl as the orthogonal protecting group at position C2 of the glycosyl acceptor. The new synthetic strategy has been performed remarkably reducing the number of purification steps, the time of synthesis (less than 72 hours) and improving the overall yield at least three times with respect to the best procedure described in the literature at the moment. Additionally, this protecting group strategy is compatible with the presence of azido groups and the use of Cu catalyzed azide alkyne cycloaddition (CuAAC) also called “click chemistry” for conjugating the α(1–2)mannobiosides to different scaffolds for the preparation of mannosyl multivalent systems.
URI: http://www.repositorio.ufop.br/handle/123456789/6693
DOI: https://doi.org/10.1039/c6ob00083e
ISSN: 1477-0539
Licença: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Fonte: o próprio artigo.
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