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Title: Rapid and efficient synthesis of α(1 – 2) mannobiosides.
Authors: Reina, José Juan
Maio, Antonio Di
Ramos Soriano, Javier
Figueiredo, Rute Cunha
Rojo Marcos, Francisco Javier
Issue Date: 2016
Citation: LÓPEZ MARTÍN, J. J. et al. Rapid and efficient synthesis of α(1 – 2) mannobiosides. Organic & Biomolecular Chemistry, v. 14, p. 2873-2882, 2016. Disponível em: <>. Acesso em: 16 jun. 2016.
Abstract: α(1,2) mannobiosides with different substituents at the reducing end have been synthesized by a common strategy using benzoyls as the permanent protecting groups and an acetyl as the orthogonal protecting group at position C2 of the glycosyl acceptor. The new synthetic strategy has been performed remarkably reducing the number of purification steps, the time of synthesis (less than 72 hours) and improving the overall yield at least three times with respect to the best procedure described in the literature at the moment. Additionally, this protecting group strategy is compatible with the presence of azido groups and the use of Cu catalyzed azide alkyne cycloaddition (CuAAC) also called “click chemistry” for conjugating the α(1–2)mannobiosides to different scaffolds for the preparation of mannosyl multivalent systems.
ISSN: 1477-0539
metadata.dc.rights.license: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Fonte: o próprio artigo.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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