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Title: Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats.
Authors: Ferreira, Patrícia Maria
Custódio, Carlos Henrique Xavier
Alzamora, Andréia Carvalho
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Keywords: Rostral ventrolateral medulla
Arterial pressure
Vascular blood flow
Spontaneously hypertensive rats
Issue Date: 2015
Citation: FERREIRA, P. M. et al. Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. Neuropeptides, Edinburgh, v. 1, p. 00-00, 2015. Disponível em: <>. Acesso em: 16 jun. 2016.
Abstract: The central and peripheral renin–angiotensin systems are known for playing a key role in cardiovascular control. In the present study,we evaluated the hemodynamic effects produced by nanoinjections of angiotensin II (Ang II) or angiotensin-(1–7) [Ang-(1–7)] into the rostral ventrolateral medulla (RVLM) of adult male normotensive (Wistar—WT) and spontaneously hypertensive rats (SHR). Animals were anesthetized (urethane 1.2 g/kg) and instrumented for recording blood pressure (BP), heart rate (HR) and blood flow (BF) in the femoral, renal or mesenteric arteries. Afterwards, rats were positioned in a stereotaxic and prepared for nanoinjections (100 nl) of saline (NaCl 0.9%), Ang-(1–7) (40 ng) or Ang II (40 ng) into the RVLM. The vascular resistance (VR)was calculated by ΔMAP/ΔBF ratio. In WT, Ang-(1–7) or Ang II caused equipotent pressor effects that were not accompanied by changes in vascular resistance. However, MAP changes were greater in SHR. This strain also showed a concomitant increase in relative vascular resistance (ΔVR/VRbaseline) of renal (0.31 ± 0.07 and 0.3 ± 0.07 vs. 0.02 ± 0.01; Ang-(1–7), Ang II and Saline, respectively) and mesenteric beds (0.3 ± 0.06 and 0.33 ± 0.04 vs. 0.05 ± 0.02; Ang-(1–7), Ang II and saline, respectively). We conclude that Ang II and Ang-(1–7) at the RVLM control the vascular resistance of renal and mesenteric beds during hypertension.
ISSN: 0143-4179
metadata.dc.rights.license: O periódico Neuropeptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3894771218803.
Appears in Collections:DECBI - Artigos publicados em periódicos

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