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Title: Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy.
Authors: Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Penitente, Arlete Rita
Bozi, Luiz Henrique Marchesi
Neves, Clóvis Andrade
Maldonado, Izabel Regina dos Santos Costa
Natali, Antônio José
Silva, André Talvani Pedrosa da
Keywords: Animal model
Cardiovascular pathology
Chagas disease
Trypanosoma cruzi
Issue Date: 2016
Citation: NOVAES, R. D. et al. Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy. Life Sciences (1973), v. 152, p. 210-219, 2016. Disponível em: <>. Acesso em: 16 jun. 2016.
Abstract: Aims: The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise programon exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility in experimental ChC. Main methods: Wistar rats were subjected to a 9-week treadmill running training and challenged with Trypanosoma cruzi. Control animals remained sedentary. Physical and metabolic performance, cardiac morphology, cytokines, chemokines, nitric oxide, oxidative tissue damage, cardiomyocyte morphology and contractility were analyzed. Key findings: Exercise training was efficient to improve physical performance and anaerobic threshold in trained animals. By increasing cardiac and serum levels of cytokines (TNF-α, IFN-γ, and IL-6), chemokines (MCP-1 and CX3CL1), the myocardial activity catalase and superoxide dismutase, and reducing lipid and protein oxidation in cardiac tissue, exercise training seem to be a beneficial strategy to mitigate the progression and severity of Chagas-associated cardiomyopathy. Significance: The protective adaptations to the host triggered by exercise training contributed to reduce cardiac parasitism, inflammation, fibrosis and cardiomyocytes atrophy. Although exercise training does not affect nitric oxide levels in cardiac tissue from infected animals, this strategy enhanced the efficiency of endogenous antioxidant mechanisms, restricting oxidative tissue damage with positive repercussions to cardiomyocytes biomechanics in rats.
ISSN: 0024-3205
metadata.dc.rights.license: O periódico Life Sciences concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3902510297103.
Appears in Collections:DECBI - Artigos publicados em periódicos

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