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dc.contributor.authorGuerra, Joyce Ferreira da Costa-
dc.contributor.authorMaciel, Poliane Silva-
dc.contributor.authorAbreu, Isabel Cristina Mallosto Emerich de-
dc.contributor.authorPereira, Renata Rebeca-
dc.contributor.authorSilva, Maísa-
dc.contributor.authorCardoso, Leandro de Morais-
dc.contributor.authorSant'Ana, Helena Maria Pinheiro-
dc.contributor.authorLima, Wanderson Geraldo de-
dc.contributor.authorSilva, Marcelo Eustáquio-
dc.contributor.authorPedrosa, Maria Lúcia-
dc.identifier.citationGUERRA, J. F. da C. Dietary açai attenuates hepatic steatosis via adiponectin-mediated effects on lipid metabolism in high-fat diet mice. Journal of Functional Foods, v. 14, p. 192-202, 2015. Disponível em: <>. Acesso em: 15 out. 2015.pt_BR
dc.description.abstractPolyphenols, especially anthocyanins, have been considered promising for the prevention of nonalcoholic fatty liver disease (NAFLD). This study investigated whether açai (Euterpe oleracea Mart.), a source of anthocyanins and recognized as one of the new “superfruits”, could alleviate high-fat diet (HFD)-induced NAFLD in mice. In HFD mice, aqueous açai extract (AAE) administration (3 g/kg) for six weeks improved insulin resistance index and increased adiponectin mRNA expression in adipose tissue and serum levels. Furthermore, AAE decreased the total liver triacylglycerol content and attenuated HFD-induced hepatic steatosis. This reduced hepatic lipid content was associated with AAE-mediated up-regulation of genes involved in adiponectin signaling, including adiponectin receptor 2, PPAR-α, and its target gene, carnitine palmitoyltransferase. Thus, dietary açai can protect liver from steatosis through its enhancement of adiponectin levels, improvement of insulin sensitivity, and increase in PPAR-α-mediated fatty acid oxidation.pt_BR
dc.subjectEuterpe oleracea martpt_BR
dc.subjectPeroxisome proliferator-activatedpt_BR
dc.subjectNonalcoholic fatty liver diseasept_BR
dc.titleDietary açai attenuates hepatic steatosis via adiponectin-mediated effects on lipid metabolism in high-fat diet mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Journal of Functional Foods concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3736991281944.pt_BR
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