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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Toledo, Juliana Oliveira | - |
dc.contributor.author | Moraes, Clayton Franco | - |
dc.contributor.author | Souza, Vinícius Carolino | - |
dc.contributor.author | Furioso, Audrey Cecília Tonet | - |
dc.contributor.author | Afonso, Luís Carlos Crocco | - |
dc.contributor.author | Córdova, Cláudio | - |
dc.contributor.author | Nóbrega, Otávio de Toledo | - |
dc.date.accessioned | 2016-01-21T11:56:06Z | - |
dc.date.available | 2016-01-21T11:56:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | TOLEDO, J. O. et al. Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α. Clinical Interventions in Aging, v. 15, p. 209-215, 2015. Disponível em: <https://www.dovepress.com/tailored-antihypertensive-drug-therapy-prescribed-to-older-women-atten-peer-reviewed-article-CIA>. Acesso em: 15 out. 2015. | pt_BR |
dc.identifier.issn | 1176-9092 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/6178 | - |
dc.description.abstract | Objective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control. Methods: Prospective study involving 110 hypertensive, community-dwelling older women with different metabolic disorders. A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension, and basal cytokine levels were measured before and after intervention. Results: Interventions were found to represent current hypertension-management practices in Brazil and corresponded to a significant reduction in systolic and diastolic BP levels in a whole-group analysis, as well as when users and nonusers of the most common therapeutic classes were considered separately. Considering all patients, mean IL-6 and TNF-α levels showed a significant decrease in circulating concentrations (P0.01) at the endpoint compared with baseline, whereas the mean INF-γ level was not significantly different from baseline values. In separate analyses, only users of antagonists of the renin–angiotensin system and users of diuretics exhibited the same significant treatment-induced reduction in serum IL-6 and TNF-α observed in the whole group. Conclusion: Our data demonstrates that a clinically guided antihypertensive treatment is effective in reversing the low-grade proinflammatory state of serum cytokines found in post¬menopausal women and support extracardiac benefits from diuretics and renin–angiotensin system antagonists | pt_BR |
dc.language.iso | pt_BR | pt_BR |
dc.subject | Renin-angiotensin system | pt_BR |
dc.subject | Hypertension | pt_BR |
dc.title | Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited. Fonte: o próprio artigo. | pt_BR |
dc.identifier.doi | https://doi.org/10.2147/CIA.S74790 | - |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_TailoredAntihypertensiveDrugs.pdf | 215,77 kB | Adobe PDF | Visualizar/Abrir |
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