Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/6083
Title: Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease.
Authors: Silva, Jaquelline Carla Valamiel de Oliveira e
Assis, Girley Francisco Machado de
Oliveira, Maykon Tavares de
Paiva, Nívia Carolina Nogueira de
Araújo, Márcio Sobreira Silva
Carneiro, Cláudia Martins
Martins Filho, Olindo Assis
Martins, Helen Rodrigues
Lana, Marta de
Keywords: Benznidazole response
Murine model
Jequitinhonha Valley - MG - Brazil
Issue Date: 2015
Citation: SILVA, J. C. V. de O. e et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Memórias do Instituto Oswaldo Cruz , v. 110, n. 1, p. 86-94, 2015. Disponível em: <http://www.scielo.br/pdf/mioc/v110n1/0074-0276-mioc-0140260.pdf>. Acesso em: 15 out. 2015.
Abstract: Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.
URI: http://www.repositorio.ufop.br/handle/123456789/6083
ISSN: 00740276
metadata.dc.rights.license: O periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante preenchimento de formulário enviado no dia 12/12/2013.
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