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Title: Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum.
Authors: Leal, Gleisiane Gomes de Almeida
Roatt, Bruno Mendes
Soares, Rodrigo Dian de Oliveira Aguiar
Carneiro, Cláudia Martins
Giunchetti, Rodolfo Cordeiro
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Francisco, Amanda Fortes
Cardoso, Jamille Mirelle de Oliveira
Mathias, Fernando Augusto Siqueira
Oliveira, Rodrigo Corrêa de
Carneiro, Mariângela
Vital, Wendel Coura
Reis, Alexandre Barbosa
Keywords: Immunophenotyping
Canine visceral leishmaniasis
Issue Date: 2014
Citation: LEAL, G. G. de A. et al. Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. Veterinary Parasitology, v. 205, p. 472-482, 2014. Disponível em: <>. Acesso em: 15 out. 2015.
Abstract: Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is associated with anemia and reductionsin eosinophils, monocytes and lymphocytes. The investigation of the immune response,based on the immunophenotypic profile of peripheral blood, showed declines in the abso-lute numbers of T lymphocytes CD5+and their subsets (CD4+and CD8+) and a drop of Blymphocytes in asymptomatic seropositive (AD-II) and symptomatic seropositive (SD) dogs.Neutrophils, when stimulated with soluble antigen of L. infantum, showed higher synthesisof interferon (IFN)- _+in AD-II and SD groups, with decreased production of interleukin
ISSN: 0304-4017
metadata.dc.rights.license: O periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732990764611.
Appears in Collections:DEACL - Artigos publicados em periódicos

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