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Title: Effect of constituents from samaras of Austroplenckia populnea (Celastraceae) on human cancer cells.
Authors: Caneschi, Carolina Milagres
Muniyappa, Mohan Kumar
Duarte, Lucienir Pains
Silva, Grácia Divina de Fátima
Santos, Orlando David Henrique dos
Spillane, Charles
Vieira Filho, Sidney Augusto
Issue Date: 2014
Citation: CANESCHI, C. M. et al. Effect of constituents from samaras of Austroplenckia populnea (Celastraceae) on human cancer cells. Journal of Intercultural Ethnopharmacology, v. 4, p. 6-11, 2015. Disponível em: <>. Acesso em: 15 out. 2015.
Abstract: Background: Aiming the continuity of the studies of Austroplenckia populnea, Brazilian species of the Celastraceae family, in the present study, it was investigated the effect of crude extracts obtained with ethanol, ethyl acetate and chloroform and two purified constituents, proanthocyanidin A and 4’-O-methylepigallocatechin, both isolated from its samaras, on cancer cell proliferation assays. Materials and Methods: The human cancer cells lines MCF-7 (ductal breast carcinoma), A549 (lung cancer), HS578T (ductal breast carcinoma) and non-cancer HEK293 (embryonic kidney cells) were treated with different concentrations of extracts and constituents and the effect was observed through the acid phosphatase method. The chemical structures of the purified compounds were identified by the respective IR and 1H and 13C nuclear magnetic resonance spectral data. Results: While crude extracts from samaras of the folk medicine A. populnea can trigger cell proliferative effects in human cell lines, the purified compounds (proanthocyanidin A and 4’-O-methyl-epigallocatechin) isolated from the same extracts can have an opposite (anti-proliferative) effect. Conclusion: Based on the results, it was possible to suggest that extracts from samaras of A. populnea should be further investigated for possible cancer-promoting activities; and the active extracts can also represent a source of compounds that have anti-cancer properties.
ISSN: 2146-8397
metadata.dc.rights.license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited. Fonte: o próprio artigo.
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