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Title: Trichomonicidal activity of Maytenus imbricata (Celastraceae).
Authors: Batista, Carla Ribeiro Álvares
Fonseca, Thaisa Helena Silva
Rodrigues, Vanessa Gregório
Sousa, Grasiely Faria de
Chacon, Michelle Oliveira
Vieira Filho, Sidney Augusto
Duarte, Lucienir Pains
Gomes, Maria Aparecida
Keywords: Metronidazole
Trichomonas vaginalis
Issue Date: 2014
Citation: BATISTA, C. R. A. et al. Trichomonicidal activity of Maytenus imbricata (Celastraceae). African Journal of Pharmacy and Pharmacology, v. 8, p. 502-506, 2014. Disponível em: <>. Acesso em: 15 out. 2015.
Abstract: Trichomoniasis, most common non-viral sexually transmitted infection worldwide, is produced by protozoan Trichomonas vaginalis. The therapy of choice is metronidazole (MTZ). The drug has undesirable side effects, which may result in treatment discontinuation, leading to further spread of infection and emergence of resistant strains. This feature highlights the importance of studying new trichomonicidal substances. In this context, the importance of plants in relation to the research of new drugs is undeniable. The genus Maytenus, distributed throughout Brazil, is the largest of family Celastraceae, including about 80 recognized species with different biological activities. Therefore, the trichomonicidal activity of MTZ and extracts obtained from Maytenus robusta leaves and Maytenus imbricata roots on the JT strain of T. vaginalis, sensitive (JT) and resistant (JTR) to MTZ was investigated. Sample of T. vaginalis trophozoites were associated with extracts in 6 increasing concentrations ranging from 0.43 to 13.76 μg/ml. The solid that precipitated from the hexane/ethyl ether - 1:1 extract (SEH), obtained from M. imbricata roots proved to be active. This extract also impacted the viability of trophozoites of both strains, with IC50 value surprisingly low (1.09 μg/ml for JT and 1.57 μg/ml for JTR) signaling towards a promising candidate for phytotherapy or for isolation of substance with trichomonicidal activity.
ISSN: 1996-0816
metadata.dc.rights.license: This article is published under the terms of the Creative Commons Attribution License 4.0 which permits copy and redistribute the material in any medium or format. Fonte: African Journal of Pharmacy and Pharmacology <>. Acesso em: 14 out 2015.
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