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Title: Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats.
Authors: Soares, Everton Rocha
Lima, Wanderson Geraldo de
Machado, Raquel do Pilar
Carneiro, Cláudia Martins
Silva, Marcelo Eustáquio
Rodrigues, Míriam Carmo
Castro, Uberdan Guilherme Mendes de
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
Keywords: Cardiac and renal remodeling
Baroreflex bradycardia
Renovascular hypertension
Issue Date: 2011
Citation: SOARES, E. R. et al. Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats. Brazilian Journal of Medical and Biological Research, v. 44, p. 573-582, 2011. Disponível em: <>. Acesso em 21 out. 2015.
Abstract: We examined the effect of exercise training (Ex) without (Ex 0%) or with a 3% workload (Ex 3%) on different cardiac and renal parameters in renovascular hypertensive (2K1C) male Fisher rats weighing 150-200 g. Ex was performed for 5 weeks, 1 h/day, 5 days/week. Ex 0% or Ex 3% induced similar attenuation of baseline mean arterial pressure (MAP, 119 ± 5 mmHg in 2K1C Ex 0%, N = 6, and 118 ± 5 mmHg in 2K1C Ex 3%, N = 11, vs 99 ± 4 mmHg in sham sedentary (Sham Sed) controls, N = 10) and heart rate (HR, bpm) (383 ± 13 in 2K1C Ex 0%, N = 6, and 390 ± 14 in 2K1C Ex 3%, N = 11 vs 371 ± 11 in Sham Sed, N = 10). Ex 0%, but not Ex 3%, improved baroreflex bradycardia (0.26 ± 0.06 ms/mmHg, N = 6, vs 0.09 ± 0.03 ms/mmHg in 2K1C Sed, N = 11). Morphometric evaluation suggested concentric left ventricle hypertrophy in sedentary 2K1C rats. Ex 0% prevented concentric cardiac hypertrophy, increased cardiomyocyte diameter and decreased cardiac vasculature thickness in 2K1C rats. In contrast, in 2K1C, Ex 3% reduced the concentric remodeling and prevented the increase in cardiac vasculature wall thickness, decreased the cardiomyocyte diameter and increased collagen deposition. Renal morphometric analysis showed that Ex 3% induced an increase in vasculature wall thickness and collagen deposition in the left kidney of 2K1C rats. These data suggest that Ex 0% has more beneficial effects than Ex 3% in renovascular hypertensive rats.
ISSN: 0100-879X
metadata.dc.rights.license: Todo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <>. Acesso em: 19 ago. 2019.
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