Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/5644
Title: Plasma cytokine response, lipid peroxidation and NF-κB activation in skeletal muscle following maximum progressive swimming.
Authors: Cleto, Lorena Sabino
Oleto, A. F.
Sousa, L. P.
Barreto, Tatiane Oliveira
Cruz, Jader dos Santos
Penaforte, Claudia Lopes
Magalhães, José Carlos de
Franco, Junia de Sousa
Pinto, Kelerson Mauro de Castro
Azevedo, Ana Carolina Campi
Vieira, Etel Rocha
Keywords: Swimming
Interleukin-6
Interleukin-10
Thiobarbituric acid reactive species
Cytokine
Issue Date: 2011
Citation: CLETO, L. S. et al. Plasma cytokine response, lipid peroxidation and NF-κB activation in skeletal muscle following maximum progressive swimming. Brazilian Journal of Medical and Biological Research, v. 44, p. 546-552, 2011. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-879X2011000600008&script=sci_arttext>. Acesso em: 16 mar. 2015.
Abstract: Our objective was to determine lipid peroxidation and nuclear factor-κB (NF-κB) activation in skeletal muscle and the plasma cytokine profile following maximum progressive swimming. Adult male Swiss mice (N = 15) adapted to the aquatic environment were randomly divided into three groups: immediately after exercise (EX1), 3 h after exercise (EX2) and control. Animals from the exercising groups swam until exhaustion, with an initial workload of 2% of body mass attached to the tail. Control mice did not perform any exercise but were kept immersed in water for 20 min. Maximum swimming led to reactive oxygen species (ROS) generation in skeletal muscle, as indicated by increased thiobarbituric acid reactive species (TBARS) levels (4062.67 ± 1487.10 vs 19,072.48 ± 8738.16 nmol malondialdehyde (MDA)/mg protein, control vs EX1). Exercise also promoted NF-κB activation in soleus muscle. Cytokine secretion following exercise was marked by increased plasma interleukin-6 (IL-6) levels 3 h post-exercise (P < 0.05). Interleukin-10 (IL-10) levels were reduced following exercise and remained reduced 3 h post-exercise (P < 0.05). Plasma levels of other cytokines investigated, monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin-12 (IL-12), were not altered by exercise. The present findings showed that maximum swimming, as well as other exercise models, led to lipid peroxidation and NF-κB activation in skeletal muscle and increased plasma IL-6 levels. The plasma cytokine response was also marked by reduced IL-10 levels. These results were attributed to exercise type and intensity.
URI: http://www.repositorio.ufop.br/handle/123456789/5644
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/S0100-879X2011007500050
ISSN: 1414-431X
metadata.dc.rights.license: Todo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 20 out. 2016.
Appears in Collections:DEEFD - Artigos publicados em periódicos

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