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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Gil, Laurent Frédéric | - |
dc.contributor.author | Han, Yongxin | - |
dc.contributor.author | Opas, Evan E. | - |
dc.contributor.author | Rodan, Gideon A. | - |
dc.contributor.author | Ruel, Réjean | - |
dc.date.accessioned | 2015-04-17T15:29:48Z | - |
dc.date.available | 2015-04-17T15:29:48Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | GIL, L. F. et al. Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis. Bioorganic & Medicinal Chemistry, v. 7, p. 901-919, 1999. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089699000450>. Acesso em: 02 fev. 2015. | pt_BR |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/5121 | - |
dc.description.abstract | Conjugates of bisphosphonates (potential bone resorption inhibitors) and prostaglandin E2 (a bone formation enhancer) were prepared and evaluated for their ability to bind to bone and to liberate, enzymatically, free PGE2. The conjugate 3, an amide at C-1 of PGE2 proved to be too stable in vivo while conjugate 6, a thioester, was too labile. Several PGE2, C-15 ester-linked con- jugates (18, 23, 24 and 31) were prepared and conjugate 23 was found to bind effectively to bone in vitro and in vivo and to liberate PGE2 at an acceptable rate. A 4-week study in a rat model of osteoporosis showed that 23 was better tolerated and more effective as a bone growth stimulant than daily maximum tolerated doses of free PGE2. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.subject | Osteoporosis | pt_BR |
dc.subject | Prostaglandin E2 | pt_BR |
dc.subject | Bisphosphonate | pt_BR |
dc.subject | Alendronate | pt_BR |
dc.subject | Conjugate | pt_BR |
dc.title | Prostaglandin E2-bisphosphonate conjugates : potential agents for treatment of osteoporosis. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | O periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3581981508139. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/S0968-0896(99)00045-0 | - |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
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ARTIGO_ProstaglandinBisphosphonateConjugates.pdf | 455,05 kB | Adobe PDF | Visualizar/Abrir |
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