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Title: Synthesis and trypanocidal activity of ent-kaurane glycosides.
Authors: Batista, Ronan
Humberto, Jorge Luiz
Chiari, Egler
Oliveira, Alaíde Braga de
Keywords: Kaurenoic acid
Koenigs–Knorr reaction
Trypanosoma cruzi
Issue Date: 2007
Citation: BATISTA, R. et al. Synthesis and trypanocidal activity of ent-kaurane glycosides. Bioorganic & Medicinal Chemistry, v. 15, p. 381-391, 2007. Disponível em: <>. Acesso em: 02 fev. 2015.
Abstract: Novel ent-kaurane glucosides were synthezised by a Koenigs–Knorr reaction between C17 and C19 alcohols derived from kaurenoic acid and 2,3,4,6-tetra-O-acetyl-glucopyranosyl bromide, followed by the hydrolysis of the acetates. Main products were assayed in vitro and in vivo against blood trypomastigote forms of Trypanosoma cruzi, the aetiological agent of Chagas’ disease (American trypanosomiasis). The results allowed to establish structure–activity relationships among these derivatives, as well as pointed out the C19-methylester-C17-O-glucoside as a potential trypanocidal agent, whose trypanocidal profile was shown to be comparable to those of gentian violet and benznidazole.
ISSN: 0968-0896
metadata.dc.rights.license: O periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3581340483210.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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