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http://www.repositorio.ufop.br/jspui/handle/123456789/4925| Title: | The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma. |
| Authors: | Assis, Leonardo Vinícius Monteiro de Locatelli, Jamille Isoldi, Mauro César |
| Keywords: | Malignant Mesothelioma Erionite/SV40 Genes and pathways |
| Issue Date: | 2014 |
| Citation: | ASSIS, L. V. M. de; LOCATELLI, J.; ISOLDI, M. C. The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma. Biochimica et Biophysica Acta, v. 1845, p. 232-247, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0304419X14000158>. Acesso em: 08 nov. 2014. |
| Abstract: | Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, aswell as, the role of several genes (p16INK4a, p14ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K,Wnt, BCL and Hippo), and their respective roles in the development of MM. |
| URI: | http://www.repositorio.ufop.br/handle/123456789/4925 |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.bbcan.2014.01.008 |
| ISSN: | 0304-419X |
| metadata.dc.rights.license: | O periódico Biochimica et Biophysica Acta concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3546550210429. |
| Appears in Collections: | DECBI - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_RoleKeyGenes.pdf | 1,24 MB | Adobe PDF | View/Open |
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