Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/4783
Title: The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice.
Authors: Pedrosa, Maria Lúcia
Silva, Marcelo Eustáquio
Silva, Marcio Eustáquio
Silva, Marcílio Eustáquio de Castro
Nicoli, Jacques Robert
Vieira, Enio Carlos
Issue Date: 1990
Citation: PEDROSA, M. L. et al. The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. Comparative Biochemistry And Physiology A, Gran Bretanha, v. 97, n.2, p. 235-243, 1990. Disponível em: <http://www.sciencedirect.com/science/article/pii/030096299090178U>. Acesso em: 20 fev. 2015.
Abstract: l. CFW mice were fed either on control diet or on iron-deficient diet. 2. After 5 months the mice were infected with CL, Y or YuYu strain of Trypanosoma cruzi. 3. On the fifth day after the infection, the mice on control diet were divided in three groups: one group remained as controls, two groups were injected either with desferrioxamine or iron-dextran. 4. The severity of the disease was evaluated by parasitemia and mortality. 5. The experimental groups were compared with the infected group fed on the control diet. 6. In mice fed on the iron-deficient diet, the disease was more severe for CL strain and less severe for Y and YuYu strains. 7. Treatment with desferrioxamine produced a less severe disease with YuYu strain and no difference with the other strains. 8. On treatment with iron-dextran, the disease became more severe with Y and CL strains; no effect was observed with YuYu strain. 9. These findings may be due to intraspecific differences among the strains.
URI: http://www.repositorio.ufop.br/handle/123456789/4783
ISSN: 10956433
metadata.dc.rights.license: O Periódico Comparative Biochemistry and Physiology Part A: Physiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3577130333774.
Appears in Collections:DEALI - Artigos publicados em periódicos

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