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Title: The effect of iron nutritional status on Trypanosoma cruzi infection in germfree and conventional mice.
Authors: Pedrosa, Maria Lúcia
Nicoli, Jacques Robert
Silva, Marcelo Eustáquio
Silva, Marcio Eustáquio
Silva, Marcílio Eustáquio de Castro
Vieira, Leda Quercia
Bambirra, Eduardo Alves
Vieira, Enio Carlos
Issue Date: 1993
Citation: PEDROSA, M. L. et al. The effect of iron nutritional status on Trypanosoma cruzi infection in germfree and conventional mice. Comparative Biochemistry And Physiology Comparative Physiology, v. 106, n. 4, p. 813-821, 1993. Disponível em: <>. Acesso em: 20 fev. 2015.
Abstract: 1. Conventional (CV) and gnotobiotic (GN) female CFW mice were infected with the Y strain of Trypanosoma cruzi. 2. After infection, both CV and GN groups received injections of iron-dextran or desferrioxamine. Non-injected mice served as controls. 3. The parasitemia was more intense in iron-dextran-treated mice. 4. The iron levels in serum, liver, and spleen were: (a) not decreased by desferrioxamine and (b) increased by iron-dextran treatments. 5. An increase in leukocyte numbers was observed in all GN and CV groups after infection. 6. There was no difference in total iron binding capacity (TIBC) and iron saturation transferrin (IST) between GN and CV mice before infection. 7. In CV groups, after infection, TIBC was decreased whereas the levels of IST were increased; in GN the opposite occurred. 8. Trypanosome-specific IgG and IgM antibody levels were raised in the GN group but not in the CV group.
ISSN: 1095-6433
metadata.dc.rights.license: O periódico Comparative Biochemistry and Physiology Part A: Physiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3577131200849.
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