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Title: Vitamin D overload and experimental Trypanosoma cruzi infection : parasitological and histopathological aspects.
Authors: Silva, Marcelo Eustáquio
Silva, Marcílio Eustáquio de Castro
Nicoli, Jacques Robert
Bambirra, Eduardo Alves
Vieira, Enio Carlos
Keywords: Vitamin D
Issue Date: 1993
Citation: SILVA, M. E. et al. Vitamin D overload and experimental Trypanosoma cruzi infection: parasitological and histopathological aspects. Comparative Biochemistry and Physiology, Londres, v. 104, n.1, p. 175-181, 1993. Disponível em: <>. Acesso em: 20 fev. 2015.
Abstract: l. Six groups of 45-day-old, 23.0 & 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LDm was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.
ISSN: 1095-6433
metadata.dc.rights.license: O periódico Comparative Biochemistry and Physiology Part A: Physiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3577160156339.
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